tgf beta signaling pathway
| PAG Title | tgf beta signaling pathway |
| PAG ID | WAG000848 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | TGF-beta regulates growth and proliferation of cells, blocking growth of many cell types. The TGF-beta receptor includes type 1 and type 2 subunits that are serine-threonine kises and that sigl through the SMAD family of transcriptiol regulators. Defects in TGF-beta sigling, includes mutation in SMADs, have been associated with cancer in humans. Prior to activation, receptor regulated SMADs are anchored to the cell membrane by factors like SARA (SMAD Anchor for Receptor Activation) that brings the SMADs into proximity of the TGF receptor kises. Binding of TGF induces phosphorylation and activation of the TGF-beta R1 receptor by the TGF-beta R2 receptor. The activated TGF-beta R1 phosphorylates SMAD2 and SMAD3, which bind to the SMAD4 mediator to move into the nucleus and form complexes that regulate transcription. SMADs regulate transcription in several ways, including binding to D, interacting with other transcription factors, and interacting with transcription corepressors and coactivators like p300 and CBP. SMAD-7 represses sigling by other SMADs to down-regulate the system. Other sigling pathways like the MAP kise-ERK cascade are activated by TGF-beta sigling, modulate SMAD activation. SnoN also regulates TGF-beta sigling, by binding to SMADs to block transcriptiol activation. TGF-beta sigling causes degradation of SnoN, releasing SMADs to regulate transcription, and also activates expression of SnoN, to down-regulate SMAD sigling at later times. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 1,290 |
| Information Content | Rich |
| Other IDs | |
| Base PAG ID | WAG000848 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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